何冰芳，二级教授，博士生导师。

个人简介：

入选江苏省“六大人才高峰”，曾获江苏省“青蓝工程”中青年学术带头人，南京市领军型科技创业人才引进计划人才项目。领衔主讲的《生物化学》课程两次被评为 “江苏省高等学校一类优秀课程”，并于2008年获评“江苏省高等学校精品课程”；参编教材2部。2006、2008年两次获得“师德十佳”称号；2008年荣获“江苏省高等学校优秀共产党员”；2011年获得江苏省“老员工最喜爱的教师”称号；2013年荣获“江苏省教育科技系统五一巾帼标兵”称号；2017年和2018年获中国商业联合会科学技术奖（全国商业科技进步奖二等奖）各1项；拼搏体育官方首批研究生“名师名导“称号。

员工培养：

指导员工获江苏省普通高校本科优秀毕业设计（论文）一等奖1人，二等奖3人。2020年第五届全国老员工生命科学创新创业大赛优秀成果奖一等奖。

指导研究生获江苏省优秀博士学位论文1人；江苏省优秀硕士学位论文2人。

主要教育经历：

1、1997/12–2001/3， University of Tsukuba (日本筑波大学)， 微生物学，博士

2、1984/9–1987/6， 中国药科大学， 生物药物学， 硕士

3、1978/9–1982/7， 中国药科大学， 药物化学， 学士

学术兼职：

1、中国微生物学会理事

2、中国生物化学与分子生物技术学会理事

3、江苏省微生物学会副理事长

4、江苏省生物化学与分子生物学学会副理事长

5、江苏省工程师学会生物医药与大健康产业专委会主任委员

6、江苏省药学会生物技术与生物药物专业委员会副主任委员

7、江苏省药学会海洋药物专业委员会副主任委员

研究方向和研究领域：

主要研究方向为微生物与生化药学、合成生物学、绿色制造。极端微生物新功能及其酶类的发现与开发、酶分子改造；重要医药中间体和小肽类药物的生物制造；生物催化合成天然产物及成药性改构与成药性评估；医用丝蛋白材料的设计与生物制造等交叉领域的研究。

研究成果：

已发表SCI/EI收录论文140余篇。申请国际和国家发明专利60多项，其中已获授权的国家发明专利近50项以及3项国际发明专利（PCT）已获得多国授权。目前主持国家重点研发计划项目课题/子课题各1项（基于成药性特征的微生物天然产物合成生物学创制，人造蛋白质合成的细胞设计构建及应用）。

近三年发表的部分论文（*通讯作者）：

[1] Baoyang Lin, Liquan Yuan, Bingbing Gao*, Bingfang He*. Patterned Duplex Fabric Based on Genetically Modified Spidroin for Smart Wound Management. Advanced Healthcare Materials, 2023, 12(4): 2370018.

[2] Xuejiao Yang*, Liquan Yuan, Yue Xu, Bingfang He*. Target-catalyzed self-assembled spherical G-quadruplex/hemin DNAzymes for highly sensitive colorimetric detection of microRNA in serum. Analytica Chimica Acta, 2023, 1247:340879.

[3] Guo Xu, Yukuan Mao, Tianyue Jiang, Bingbing Gao*, Bingfang He*. Structural design strategies of microneedle-based vaccines for transdermal immunity augmentation. Journal of Controlled Release, 2022, 351: 907-922.

[4] Cheng Cheng, Qingyun Sun, Xiuping Wang, Bingfang He*, Tianyue Jiang*. Enzyme-manipulated hydrogelation of small molecules for biomedical applications. Acta Biomaterialia, 2022, 151:88-105.

[5] Cheng Cheng, Yumeng Qiu, Shimeng Tang, Baoyang Lin, Maoze Guo, Bingbing Gao*, Bingfang He*. Artificial Spider Silk Based Programmable Woven Textile for Efficient Wound Management. Advanced Functional Materials, 2022, 32(6): 2107707.

[6] Jianlin Chu, Yani Tian, Qian Li, Gaofei Liu, Qi Yu, Tianyue Jiang*, Bingfang He*.

Engineering the β-Fructofuranosidase Fru6 with Promoted Transfructosylating Capacity for Fructooligosaccharide Production. J. Agric. Food Chem., 2022, 70(31): 9694-9702.

[7] Yun Shao, Kaiyi Dong, Xinyu Lu, Bingbing Gao*, Bingfang He*. Bioinspired 3D-Printed MXene and Spidroin-Based Near-Infrared Light-Responsive Microneedle Scaffolds for Efficient Wound Management. ACS Applied Materials & Interfaces, 2022, 14(51): 56525-56534.

[8] Bingbing Gao*, Maoze Guo, Kai Lyu, Tianshu Chu, Bingfang He*. Intelligent Silk Fibroin Based Microneedle Dressing (i-SMD). Advanced Functional Materials, 2021, 31(3):2006839.

[9] Maoze Guo, Yuqiu Wang, Bingbing Gao*, Bingfang He*. Shark Tooth-Inspired Microneedle Dressing for Intelligent Wound Management. ACS Nano, 2021, 15(9): 15316-15327.

[10] Maoze Guo, Qian Li, Bingbing Gao*, Bingfang He*. One-step 3D printed intelligent silk fibroin artificial skin with built-in electronics and microfluidics. Analyst, 2021, 146:5934-5941.

[11] Yuqiu Wang, Maoze Guo, Bingfang He*, Bingbing Gao*. Intelligent Patches for Wound Management: In situ sensing and Treatment. Analytical Chemistry, 2021, 93(11): 4687-4696.

[12] Tianyue Jiang, Yudi Ma, Xiao Xu, Qingchun Ji, Mingxing Feng, Cheng Cheng, Yang Feng, Bingfang He*, Ran Mo*. Enzyme-instructed hybrid nanogel/nanofiber oligopeptide hydrogel for localized protein delivery. Acta Pharmaceutica Sinica B, 2021, 11(7): 2070-2079.

[13] Tianyue Jiang, Chendan Liu, Xiao Xu, Bingfang He*, Ran Mo*. Formation Mechanism and Biomedical Applications of Protease-Manipulated Peptide Assemblies. Frontiers in Bioengineering and Biotechnology, 2021, 9: 598050.

[14] Lupeng Cui, Yumeng Qiu, Yu Liang, Chunjie Du, Weiliang Dong, Cheng Cheng*, Bingfang He*.  Excretory expression of IsPETase in E. coli by an enhancer of signal peptides and enhanced PET hydrolysis. Int. J. Biol. Macromol., 2021, 188:568-575.

[15] Tianyi Chen, Ziyi Chen, Nan Wang, Jianlin Chu, Bo Fan, Cheng Cheng, Song Qin*, Bingfang He*. Highly Regioselective and Efficient Biosynthesis of Polydatin by an Engineered UGT_BL1-AtSuSy Cascade Reaction. J. Agric. Food Chem., 2021, 69(31):8695-8702.

[16] Gaofei Liu, Xin Tong, Jialing Wang, Bin Wu, Jianlin Chu*, Yongchan Jian, Bingfang He*. Reshaping the binding pocket of purine nucleoside phosphorylase for improved production of 2-halogenated-2'-deoxyadenosine. Catalysis Science & Technology, 2021, 11:4439-4446.

[17] Anni Li, Cheng Cheng, Weimin Qi, Xin Pan, Xuanping Xu,Xinyu Wang, Chunying Wu, Jianlin Chu*, Bingfang He*. Combing multiple site-directed mutagenesis of penicillin G acylase from Achromobacter xylosoxidans PX02 with improved catalytic properties for cefamandole synthesis. Int. J. Biol. Macromol., 2021, 175:322-329.

[18] Jianlin Chu, Jiheng Yue, Song Qin, Yuqiang Li, Bin Wu*, Bingfang He*. Biocatalysis for Rare Ginsenoside Rh2 Production in High Level with Co-Immobilized UDP-Glycosyltransferase Bs-YjiC Mutant and Sucrose Synthase AtSuSy. Catalysts, 2021, 11(1):132.

[19] Lu Zhao, Xiaoli Xu, Yani Tian, Bailu Pang, Jianlin Chu*, Bingfang He*. Single site mutations of glycosyltransferase with improved activity and regioselectivity for directed biosynthesis of unnatural protopanaxatriol-type ginsenoside product. Molecular Catalysis, 2021, 515: 111937.

[20] Jingxuan Zhang, Bingbing Gao, Kai Lv, Lot Kumissay, Bin Wu, Jianlin Chu*, Bingfang He*. Specific immobilization of lipase on functionalized 3D printing scaffolds via enhanced hydrophobic interaction for efficient resolution of racemic 1-indanol. Biochem. Bioph. Res. Co., 2021, 546:111-117.

E-mail: bingfanghe@njtech.edu.cn