李学明，教授，博士生导师，拼搏体育官方经理。

个人简介：

南京药学会常务理事、江苏省药学会药剂专委会副主任委员、江苏省药学会促进医药产业发展专委会委员、中国药品监督管理研究会药品包材与辅料专委会委员等，兼任国家药监局药品审评专家、江苏省药监局药品审评专家、国家高新技术企业审评专家等。被评为江苏省“青蓝工程”优秀青年骨干教师，南京市有突出贡献中青年专家，获中国产学研合作创新奖。

多年来一直从事药剂学、药物动力学、药用高分子材料学等方面的教学科研工作，主持或承担了国家“重大新药创制”、国家自然科学基金、江苏省自然科学基金等多项国家和省部级项目，以及多项企业合作课题。发表学术论文100余篇，获得发明专利授权20余项。指导的研究生曾获“挑战杯”全国老员工课外学术科技作品二等奖，指导的本科生曾获江苏省优秀毕业论文一等奖。

2012年及2015年在国家药品审评中心担任外聘专家从事药品技术审评工作。2015年7月-2016年7月在美国密歇根大学拼搏体育官方做访问学者。

主要研究方向：

递药新技术、缓控释制剂、生物医学新材料等。

近期代表性论文：

1. Shuilin Shen, Zimeng Zhang, Haixiao Huang, Jing Yang, Xinyue Tao, Zhengjie Meng, Hao Ren* and Xueming Li*. Copper-induced injectable hydrogel with nitric oxide for enhanced immunotherapy by amplifying immunogenic cell death and regulating cancer associated fbroblasts[J]. Biomaterials Research, 2023, 27:44 (IF:15.863/ Q1)

2. Jing Yang, Yunhao Bai, Shuilin Shen, Xinyue Tao, Chengyu Ma, Bowen Fu, Qihao Dai, Jian Wu, Zhengjie Meng, Qingmin Sun*, Xueming Li*, Hao Ren*. An Oral Nano-antioxidant for Targeted Treatment of Inflammatory Bowel Disease by Regulating Macrophage Polarization and Inhibiting Ferroptosis of Intestinal Cells[J]. CHEM ENG J, 2023, 465: 142940 (IF:16.744/Q1)

3. Zhengjie Meng, Bowen Fu, Zheng Yang, Yuhua Xu, Haixiao Huang, Yunhao Bai, Xue Fang, Shuilin Shen, Jing Yang, Jiahui Yong, Xinyue Tao, Chenyu Ma, Wenjun Miao, Hao Ren, Yonglu Wang*, Hao Xu*, Xueming Li*. Polydopamine-coated thalidomide nanocrystals promote DSS-inducedmurine colitis recovery through Macrophage M2 polarization together withthe synergistic anti-inflammatory and anti-angiogenic effects. INT J PHARMACEUT, 2023, 630: 122376 (IF 6.510/Q1)

4. Zhengjie Meng*, Xue Fang, Bowen Fu, Cheng Qian, Zheng Yang, Yunhao Bai, Xinyue Tao, Haixiao Huang, Chenyu Ma, Wenjun Miao, Hao Ren, Aiyun Wang*, Xueming Li*. Tumor immunotherapy boosted by R837 nanocrystals through combining chemotherapy and mild hyperthermia[J]. J CONTROL RELEASE, 2022, 350: 841–856 (IF: 11.467/Q1)

5. Ren Hao*, Yong Jiahui, Yang Qingqing, Yang Zhen, Liu Zhangya, Xu Yan, Wang Hao, Jiang Xing, Li Xueming*. Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy[J]. ACTA PHARM SIN B, 2021，11(10): 3244-3261 (IF: 14.903/Q1)

6. Meng Zhengjie*, Wang Hao, Fang Xue, Liu Zhangya, Yang Zhen, Yong Jiahui, Yang Qingqing, Bai Yunhao, Ren Hao, Xu Hao*, Li Xueming*. Surface Decoration via Physical Interaction of Cupric Diethyldithiocarbamate Nanocrystals and Its Impact on Biodistribution and Tumor Targeting. ACS APPL MATER INTER, 2021, 13(31): 36894-36908. (IF: 10.383/Q1)

7. Hao Ren*, Qingqing Yang, Jiahui Yong, Xue Fang, Zheng Yang, Zhangya Liu, Xing Jiang, Wenjun Miao a and Xueming Li*. Mitochondria targeted nanoparticles to generate oxygen and responsive-release of carbon monoxide for enhanced photogas therapy of cancer. BIOMATER SCI, 2021, 9: 2709-2720 (IF: 7.590/Q1)

8. Yan Xu, Jiwei Liu, Zhangya Liu, Hao Ren,* Jiahui Yong, Weilan Li, Hao Wang, Zheng Yang, Yonglu Wang, Guoguang Chen*, and Xueming Li*. Blockade of Platelets Using Tumor-Specific NO-Releasing Nanoparticles Prevents Tumor Metastasis and Reverses Tumor Immunosuppression. ACS Nano, 2020, 14: 9780-9795 (IF: 18.027/Q1)

9. Jiwei Liu, Yan Xu, Zhe Liu, Hao Ren, Zhengjie Meng, Kuntang Liu, Zhangya Liu, Jiahui Yong, Yonglu Wang^＊, Xueming Li^＊. A modified hydrophobic ion-pairing complex strategy for long-term peptide delivery with high drug encapsulation and reduced burst release from PLGA microspheres. EUR J PHARM BIOPHARM, 2019, 144: 217-229 (IF: 5.589/Q1)

10. Yuqian Wang, Zhangya Liu, Hao Wang, Zhengjie Meng, Yonglu Wang, Wenjun Miao, Xueming Li^＊, Hao Ren^＊. Starvation-amplified CO generation for enhanced cancer therapy via erythrocyte membrane-biomimetic gas nanofactory. ACTA BIOMATER, 2019, 92: 241-253 (IF: 10.633/Q1)

近期代表性专利：

1. 李学明，王永禄，刘坤堂，陈卫，王栋，李杨，孟政杰，任浩。一种莫沙必利的微孔渗透泵控释片及其制备方法。专利号：ZL 201910322984.8，授权日期：2023.05.05

2. 李学明、刘吉伟、王永禄、任浩、孟政杰、徐妍、陈卫、王栋、李杨。一种抑制PLGA微球中多肽类药物酰化副反应的方法。专利号：ZL 201910387385.4，授权日期：2023.04.07

3. 李学明，任浩，王雨倩，王永禄，孟政杰，陈卫，王栋。一种生物酶催化产气抗肿瘤仿生纳米粒及其制备方法。专利号：ZL201910269453.7，授权日期：2021.09.03

4. 李学明，王永禄，李杨，王栋，陈卫，任浩，刘坤堂，刘吉伟。一种莫沙必利的缓释干混悬剂及其制备方法。专利号：ZL201710692217.7，授权日期：2021.07.02

5. 李学明，陈卫，王永禄，王栋，孙小虎。一种硝苯地平缓释片及其制备方法。专利号：ZL201810120465.9，授权日期：2020.11.03

Email: xuemingli@njtech.edu.cn