王玉斌，副研究员，硕士研究生导师， 药物化学教研室副主任。

教育背景：

2003.9-2008.7 中国药科大学 药物化学 博士

1999.9-2003.7 中国药学大学 药物制剂 学士

工作经历：

2013.7至今 拼搏体育官方 拼搏体育官方 副研究员

2013.7-2014.7 美国哈佛大学 访问学者

2010.5-2013.7 拼搏体育官方 拼搏体育官方 助理研究员

2008.7-2010.5 台湾旭富医药科技有限公司南京研发中心 工程师

研究方向：

1、抗肿瘤新药的设计合成和生物活性研究；

2、原料药绿色合成工艺开发；

3、仿制药的注册申报，包括QbD理念下的合成工艺开发、产业化中试放大、药品质量研究；

4、全过程的杂质研究与控制，从原料药到制剂的杂质谱研究，涵盖杂质的分离与鉴定、基因毒性杂质研究、元素杂质研究等。

近期发表的部分论文：

1、S. Xia, Y. Jian, L. Zhang, C. Zhang, Y. An* and Y. Wang*, Visible-light-promoted N–H functionalization of O-substituted hydroxamic acid with diazo esters, Rsc Advances. 2023, 13, 14501-14505.

2、X. Liu⁺, Y. Shen⁺, C. Lu, Y. Jian, S. Xia, Z. Gao, Y. Zheng, Y. An*, Y. Wang*, Visible-light-driven PhSSPh-catalyzed regioselective hydroborylation of α,β-unsaturated carbonyl compounds with NHC-boranes, Chemical Communications. 2022, 58, 8380-8383.

3、H. Wan, S. Xia, X. Liu, Y. Jian, Y. An*, Y. Wang*, Synthesis of spirocyclic oxazole derivatives from 2-aryldene cycloalkanones and α-halohydroxamates, Organic & Biomolecular Chemistry . 2022, 20, 4293-4297.

4、P. Lu,  X. Liu, X. Yuan, M. He, Y. Wang*, Q. Zhang , P. Ouyang；Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening，ACS Chemical Biology，2016，11，1901−1907

5、P. Lu, Y. Guo, L. Zhu, Y. Xia, Y. Zhong, Y. Wang*; A novel NAE/UAE dual inhibitor LP0040 blocks neddylation and ubiquitination leading to growth inhibition and apoptosis of cancer cells，European Journal of Medicinal Chemistry，2018，154，294-304

6、X. Yuan, Y. Xia, Lu P, L. Zhu, Y. Zhong, Y. Wang*; Synthesis and evaluation of 1H-pyrrole-2,5-dione derivatives as cholesterol absorption inhibitors for suppressing the formation of foam cells and inflammatory response，Bioorganic & Medicinal Chemistry，2018，26，1435-1447

7、Y. Yuan, P. Lu, X. Xue, H. Qin, C. Fan, Y. Wang*, Q. Zhang; Discovery of 2-azetidinone and 1H-pyrrole-2,5-dione derivatives containing sulfonamide group at the side chain as potential cholesterol absorption inhibitors，Bioorganic & Medicinal Chemistry Letters，2016，26，849–853

8、Y. Wang, H. Liu, P. Lu, R. Mao, X. Xue, C. Fan, J. She; Design, Synthesis, and In Vitro Evaluation of Novel 3,7-Disubstituted Coumarin Derivatives as Potent Anticancer Agents，Chemical Biology & Drug Design，2015，86，637-647

9、P. Lu, Y. Wang*, P. Ouyang, J. She, M. He；3D-QSAR Based Pharmacophore Modeling and Virtual Screening for Identification of Novel G Protein-Coupled Receptor40 Agonists, Current Computer-Aided Drug Design，2015， 11，51-56 Lu P, Y. Wang*, Ma B, She JX, Zhang Q, He MF, Liu Y; Pharmacophore-Based Discovery of New Human DihydroorotateDehydrogenase Inhibitor，Medicinal Chemistry，2014，10，402-408

10、X. Xue, Y. Wang*, P. Lu, H. Shang, J. She, L. Xia, H. Qian, W. Huang; Synthesis and in Vitro Evaluation of 1,3,4Thiadiazol-2-yl UreaDerivatives as Novel AChE Inhibitors, Chemical & Pharmaceutical Bulletin，2014，62（6），524-527

11、C. Fan, Y. Wang*, P. Lu, X. Xue, J. She; Synthesis and Biological Evaluation of Novel N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl)Methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) Formamide as a Potent Immunosuppressant Agent; Letters in Drug Design & Discovery，2014，11，375-379

12、L. Zhu, P. Lu, L. Gong, C. Lu, M. Li, Y. Wang*；Design, Synthesis, and Biological Evaluation of 4-amino Substituted 2H-chromen-2-one Derivatives as an NEDD8 Activating Enzyme Inhibitor in Pancreatic Cancer Cells, Medicinal Chemistry, 2020, 16, 969-983

13、Y. Xia, L. Zhu, X. Yuan, Y. Wang*; Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress, Chem. Biodiversity 2019, 16, e1800189

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