孙阳，副教授，硕士生导师。

教育经历：

2013/09–2016/06 中国药科大学 药理学 博士

2008/09–2011/06 北京协和医学院 药理学 硕士

2004/09–2008/06 中国药科大学 海洋药学 学士

工作经历：

2016/09–2018/11 拼搏体育官方 拼搏体育官方 讲师

2018/12至今 拼搏体育官方 拼搏体育官方 副教授，硕士生导师

研究方向：

1. 中药天然产物、候选化合物等的抗炎、抗肿瘤、抗纤维化和抗抑郁症药物作用及其作用机制研究（药物新靶点的发现和验证研究）

2. 细胞、血清等生物样本的GC-MS、LC-MS代谢组学研究

3. 炎症性肠病相关的肠道菌群分析研究

研究成果：

1. 主持、参加或完成的科研项目：

（1）国家自然科学基金青年基金，No.81703556，基于SphK1/S1P/YAP通路的黄芩苷对炎症相关性癌症的抑制作用及其机制研究，20.10万元，，主持

（2）江苏省自然科学基金青年基金，No.BK20171024，SphK1/S1P/YAP通路为靶标的黄芩苷基于炎症微环境的抗肿瘤作用及其机制研究，20万元，主持

（3）国家自然科学基金面上基金，No. 81773802，睾丸支持细胞缝隙连接蛋白Cx43在糖尿病诱发生精功能障碍中的调控机制及桃叶珊瑚苷保护作用研究，48万元，参与

（4）江苏省先进生物制造创新中心（重点项目），No. XTC2203，源于生物制造的虫草提取物改善肺炎/肺癌/肺纤维化、糖尿病并发症和神经病变的作用及其机制研究，50万元，参与

（5）南京市生命健康科技专项-临床前沿技术突破, No. 202110015, 靶向骨肉瘤转移调控机理的体外评价体系的建立及其在新药研发和早期诊断中的应用， 100万元，参与

2. 以第一/通讯作者在Cell death & disease、Biochemical Pharmacology、Phytomedicine、Journal of Agricultural and Food Chemistry、Chemico-Biological Interactions等杂志发表SCI 论文15篇，其中影响因子（IF）>5的论文10篇，总引用次数557次，单篇最高引用次数124次，累计影响因子为71.092。

1)Xiaoming Chai, Mengyue Pan, Jingjie Wang, Mingmei Feng, Yupeng Wang, Qi Zhang*, Yang Sun*. Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway. Biochemical and Biophysical Research Communications. 2022;637:127-135. (IF 3.322)

2) Runyu Yang, Hanxi Yu, Jiaxi Chen, Jianwei Zhu, Changqin Song, Lvqi Zhou, Yang Sun*, Qi Zhang*. Limonin attenuates LPS-induced hepatotoxicity by inhibiting pyroptosis via NLRP3/Gasdermin D signaling pathway. Journal of Agricultural and Food Chemistry. 2021;69:982-991. (IF 5.895)

3) Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang*, Yang Sun*. Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling. International Immunopharmacology. 2021;90:107161. (IF 5.714)

4) Runyu Yang, Changqin Song, Jiaxi Chen, Lvqi Zhou, Xiubo Jiang, Xiaomei Cao, Yang Sun*, Qi Zhang*. Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1. Phytomedicine. 2020;69:153211-153224. (IF 6.656)

5) Lvqi Zhou, Hao Ning, Xiaotian Li, Jiaxi Chen, Runyu Yang, Changqin Song, Yang Sun*, Qi Zhang*. Nattokinase mitigated dextran sulfate sodium-induced chronic colitis by regulating microbiota and suppressing tryptophan metabolism via inhibiting IDO-1. Journal of Functional Foods. 2020;75:104251. (IF 5.223)

6) Xiubo Jiang, Zhenhao Zhang, Changqin Song, Hanzhi Deng, Runyu Yang, Lvqi Zhou, Yang Sun*, Qi Zhang*. Glaucocalyxin A reverses EMT and TGF-β1-induced EMT by inhibiting TGF-β1/Smad2/3 signaling pathway in osteosarcoma. Chemico-Biological Interactions. 2019;307:158-166. (IF 3.723)

7) Ying Lu^#, Yang Sun^#,*, Jianwei Zhu^#, Lisha Yu, Xiubo Jiang, Jie Zhang, Xiaochen Dong, Bo Ma*, Qi Zhang*. Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway. Cell Death & Disease. 2018;9(1):15. (IF 5.959)

8) Jianwei Zhu^#, Yang Sun^#,*, Ying Lu, Xiubo Jiang, Bo Ma, Lisha Yu, Jie Zhang, Xiaochen Dong*, Qi Zhang*, Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway. Cell Death & Disease. 2018;9 (6):708. (IF 5.959)

9) Yang Sun*, Xiubo Jiang, Ying Lu, Jianwei Zhu, Lisha Yu, Bo Ma, Qi Zhang*. Oridonin prevents epithelial-mesenchymal transition and TGF-β1-induced epithelial-mesenchymal transition by inhibiting TGF-β1/Smad2/3 in osteosarcoma. Chemico-Biological Interactions. 2018;296:57-64. (IF 3.407)

10) Yang Sun, Yue Zhao, Jing Yao, Li Zhao, Zhaoqiu Wu, Yu Wang, Di Pan, Hanchi Miao, Qinglong Guo*, Na Lu*. Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation. Biochemical Pharmacology. 2015;94(2):142-54. (IF 5.091)

11) Yang Sun^#, Yue Zhao^#, Xiaoping Wang, Li Zhao, Wenjun Li, Youxiang Ding, Chuyue Pan, Qinglong Guo*, Na Lu*. Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer cell proliferation in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway. Oncotarget. 2016;7(23):34300-15. (IF 5.008)

12) Xiaoping Wang^#, Yang Sun^#, Yue Zhao, Youxiang Ding, Xiaobo Zhang, Lingyi Kong, Zhiyu Li, Qinglong Guo*, Li Zhao*. Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation. Biochemical Pharmacology. 2016;106:70-81. (IF 5.091)

13) Yue Zhao^#, Yang Sun^#, Youxiang Ding, Xiaoping Wang, Yuxin Zhou, Wenjun Li, Shaoliang Huang, Zhiyu Li, Qinglong Guo* and Na Lu*. GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1expression via activation of AMPK/FOXO3a pathway. Oncotarget. 2015;6(28):26291-307. (IF 5.008)

14) Yang Sun^#, Zeqin Lian^#, Chunying Jiang, Yinghong Wang*, Haibo Zhu*. Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. PLoS One. 2012;7(3):32115 (IF 4.092)

15) Yang Sun, Yinghong Wang, Kai Qu, Haibo Zhu*. Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters. Journal of Asian Natural Products Research. 2011;13(6):534-546 (IF 0.944)

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